Judd Trump launches his quest for a fourth World Grand Prix title against Ben Woollaston at the Coventry Building Society Arena on Tuesday.
The Ace is the most successful player in the history of the elite event, having lifted the trophy in 2015, 2019 and 2020.
An ever-present at the tournament since it began six years ago, Trump arrives having already captured the Champion of Champions and reached two ranking event quarter-finals this term.
The world number two has also won nine of his 10 previous meetings with Woollaston, who is making his first appearance in the event since 2016 after reaching the last 16 of the UK Championship and Scottish Open.
Neil Robertson is one of two other former champions in action on day two; the 2020 winner facing Noppon Saengkham.
Although the English Open winner, who missed the Scottish Open through illness, has only progressed beyond the second round twice in his seven previous appearances.
Barry Hawkins – the 2017 champion – looks to build on his run to the UK Championship semi-finals against Mark Selby, who is seeded 21st in Coventry following a difficult start to the campaign.
A four-time runner-up this season, John Higgins’ latest quest for silverware begins against Tom Ford – although the four-time World champion has only reached the quarter-finals of this tournament on one previous occasion.
Meanwhile, Anthony McGill faces Stephen Maguire for a second battle of the Glaswegians in the space of a week, with McGill prevailing 5-3 in their Scottish Open quarter-final showdown last time out.
Northern Ireland Open champion Mark Allen has never been past round two. The Pistol plays Cao Yupeng, who he famously accused of cheating an unsporting behaviour following their showdown at the 2012 World Championship.
Elsewhere, 2016 finalist Stuart Bingham seeks an eighth straight victory over Ricky Walden, while Championship League winner David Gilbert goes up against two-time Crucible runner-up Ali Carter.
Play gets underway at 1pm GMT on Tuesday with all matches contested over the best of seven frames at the Coventry Building Society Arena.
World Grand Prix Snooker 2021 Day Two Schedule
Tuesday December 14
6 Barry Hawkins v Mark Selby
11 Ricky Walden v Stuart Bingham
8 John Higgins v Tom Ford
12 David Gilbert v Ali Carter
7 Judd Trump v Ben Woollaston
10 Anthony McGill v Stephen Maguire
4 Neil Robertson v Noppon Saengkham
5 Mark Allen v Cao Yupeng